Working on CDMO for Macromolecular Target Drugs
By adopting advanced analytical methods and conducting comprehensive analysis of products from physical, chemical, and other perspectives, whether it is characterizing reference materials at different stages, evaluating products from different batches, or conducting comparative studies on biosimilars or improved biopharmaceuticals, all will meet scientific standards and international regulatory requirements.
◆ Peptide level: amino acid sequence, composition, modification analysis, N/C end sequence analysis, N-glycosidic/O-glycosidic site analysis, disulfide bonds, peptide maps/spectrograms, etc
◆ Protein level: intact molecular weight, deglycemic molecular weight
◆ Subunit level: reducing molecular weight, de sugar reducing molecular weight
◆ Advanced structures: UV spectroscopy, fluorescence spectroscopy, Raman spectroscopy, thermal stability, circular dichroism
◆ Physical and chemical properties research: protein content (extinction coefficient research), amino acid composition analysis, glycated protein, sialic acid content, sugar type (N-glycoside/O-glycoside), free thiol group content, size heterogeneity, charge heterogeneity